With the continuous progress of human medical technology, the contemporary medical field gradually shifted from molecular therapy to cell therapy.

Cell therapy refers to the treatment method that uses the adult cells (or stem cells) of the patient to repair tissues and organs. It is widely used in bone marrow transplantation, advanced liver cirrhosis, femoral head necrosis, malignant tumor, myocardial infarction and other diseases.

Cell therapy is a century-old one. The first cell therapy concept dates back to 1493 to 1541 and was proposed by the Filipino scholar Auredus Paracelsus. In 1912, German doctors used cell therapy for the first time in the treatment of "pediatric hypothymus and hypothyroidism". In 1930, The Swiss generation of Paul Nihans (Daul Niehans, 1882-1971) became a famous physician of cell therapy and skin rejuvenation, and was known as the "father of cell therapy".

According to the cell type, cell therapy can be divided into immune cell therapy, stem cell therapy, and other somatic cell therapies.

According to the cell source, cell therapy can be divided into autologous cell therapy and allogeneic cell therapy.

According to the technique type, cell therapy can be divided into non-gene-edited cell therapy and gene-edited cell therapy. The former directly uses human cells such as stem cells to repair or reconstruct normal cells; the latter is gene edited by human cells before treatment to achieve the effect of treating a disease.

Cell therapy has been applied in many fields, especially for those that are difficult to cure or to which traditional therapies are not applicable. Here are some areas of cell therapy applications:

Hematological disorders: Cell therapy has been widely used in the treatment of multiple myeloma, leukemia, lymphoma and other hematological diseases;

Immune system disease: "autoimmune disease" is the immune system to its own body components, causing damage and disease. Including: rheumatoid arthritis, scleroderma, systemic lupus erythematosus, adolescent diabetes, a variety of skin diseases;

Neurological diseases: including the use of autologous cell therapy in the treatment of multiple sclerosis, Parkinson's disease, spinocerebellar atrophy, ataxia and other neurological diseases;

Skeletal system diseases: bone marrow stem cell therapy has been widely used in the treatment of skeletal system diseases, such as fracture, osteoporosis, arthritis, etc.;

Skin disorders: Autologous stem cell therapy has been used to treat some epidermal diseases, such as burns, skin defects, and trauma.

Cell therapy is widely used in the field of cancer, including lung cancer (small cell lung cancer, squamous carcinoma, adenocarcinoma), liver cancer, gastric cancer, colorectal cancer, kidney cancer, acute and chronic leukemia, lymphoma, malignant melanoma, breast cancer, prostate cancer, etc.

By 2022, there are 33 approved cell therapy products worldwide, including 12 immune cell products and 21 stem cell products. The global cell therapy industry is in a stage of rapid development.

With the rapid development of medical technology, stem cell therapy is one of the most cutting-edge treatments.

Recently, DVC STEM released a comprehensive overview of stem cell therapy in 2023, which detailed the science of stem cell therapy, the scope of application, stem cell anti-aging, treatment of chronic diseases and other aspects, and obtained the PubMed review evidence support.

Many people know about stem cells, but they don't know exactly what they do. The people around are beating stem cells, what is the use? What diseases can be treated? Let's get to know it together?

Stem cell therapy

Stem cell therapy is a method for disease treatment using the differentiation potential of stem cells.

Stem cells can differentiate into multiple functional cells under certain conditions. Transplantation of healthy stem cells or stem cell exosomes into patients can replace or repair the damaged cells or tissues, thus achieving the purpose of treating the disease.

List of stem cell therapy diseases

Stem cells are known as the original material of life. From neurodegenerative disease to heart disease, from diabetes to autoimmune diseases, stem cell therapy is constantly expanding its therapeutic field.

 Statistics show, clinical trials of mesenchymal stem cells involve hundreds of diseases. Neurological, cardiovascular and orthopedic diseases are the three main research areas, accounting for more than 15%, and more than half of the total. In addition, the proportion of diabetes mellitus and GVHD is about 5%, which is an important research direction for the clinical application of mesenchymal stem cells.

At present, there are already international mesenchymal stem cell therapy products approved on the market. According to statistics, there are more than 13 stem cell therapy drugs on the market worldwide, the vast majority of which are mesenchymal stem cell products. As clinical trials begin, more MSC therapy products will be approved in the future, and more patients will benefit.

Various types of stem cells, including hematopoietic, mesenchymal, and induced pluripotent stem cells, have been used in clinical trials and therapies. Below is a list of stem cell-treated diseases:

Note: The above list is provided by the National Library of Medicine (www.ncbi.nlm.nih. Gov) review passed, for reference only

In this list, we can see that stem cell therapy has achieved remarkable results in several areas.

In recent years, further clinical studies on stem cell therapy have been carried out around the world. The United States, The United Kingdom, Japan and other developed countries took the lead in using stem cell transplantation to treat diseases, and achieved good results. In China, many hospitals have also carried out clinical studies of mesenchymal stem cells in the treatment of diseases. The application of stem cell technology therapy, can be said to be incomparable to many traditional methods.

According to relevant data, the world more than 6000 in stem cell clinical trials involving hundreds of diseases, including spinal cord injury, multiple sclerosis, stroke, amyotrophic lateral sclerosis, Alzheimer's, osteoarthritis, femoral head necrosis, disc degeneration, myocardial infarction, cirrhosis, Crohn's disease, interstitial lung disease, systemic lupus erythematosus, erectile dysfunction and premature ovarian failure, and so on.

With the continuous development of technology, stem cells will certainly trigger a medical revolution, and become the third way of treatment after drugs and surgery. A series of difficult diseases that are difficult to treat by various diseases will eventually be gradually rescued.

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